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The SemaCyte® Multiplex Platform: Unravelling Nutlin-3a Cytotoxicity and p53 Induction
Applications
In this study, we employ a 4-plex cell panel as a proof of concept. Our results demonstrate that the SemaCyte® Multiplex platform establishes meaningful and biologically plausible associations between Nutlin-3a cytotoxicity and p53 induction. Specifically, we investigate A549, PC3, T98G, and HepG2 cells, which were pooled and exposed to serial dilutions of Nutlin-3a.
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The SemaCyte® Multiplexing Platform: Accelerating Image-Based Cell Panel Screening
Platform
The SemaCyte Multiplexing Platform pools diverse cell types within a single well, for a 6-fold reduction in screening time and 10-fold reduction in cost. This technology note outlines the platform, the workflow, the data analytics, and its potential.
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Enhancing Cell Assay Efficiency: Rapid Assessment of A549 Cells Frozen on SemaCyte® Microcarriers
Applications
SemaCyte® microcarriers enables cryopreservation of fully adherent A549 cells in standard cryovials. Batch production ensures uniformity across longitudinal studies.
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Poster - High-Order Cell Multiplexing for Image-Based Assays with the SemaPlex Platform
Applications
SemaCyte Multiplex platform to optically barcode cell microcarriers to enable true high-order cell multiplexing for image-based assays. We present a proof-of-concept 4-plex oncology cell panel screen for p53 stabilisation.
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Product Protocol - SemaCyte® Seeding Dish 20 Multiplex (SD20-MX)
Platform
Protocol to generate adherent assay-ready cells on SemaCyte® microcarriers, pool barcoded cells, and perform multi-day drug assays with immunostaining endpoints.
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Product Protocol - SemaCyte® Seeding Dish 20 (SD20)
Platform
Basic protocol to generate adherent assay-ready cells on SemaCyte® microcarriers.
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SemaCyte® Microcarriers Platform - Brochure
Platform
The SemaCyte® Microcarrier Platform leverages novel materials physics to move and freeze adherent cells. Our approach introduces flexibility, speed, and into existing drug discovery workflows.
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SemaCyte® Microcarriers for Flexible Imaging Assays
Applications
SemaCytes increase the workflow flexinility during drug screening assays with live or fixed cell imaging.
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SemaCyte® Microcarriers for Multi-Day Drug Sensitivity Assays
Applications
Assay-ready A549 seeding shuttles for multi-day drug sensitivity assays against Nutlin-3A and Trametinib
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Protocol for the Preparation and Use of SemaCytes
Platform
Overview of how to generate and use SemaCytes for standard cell assays
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SemaCyte® Microcarriers for Assay-Ready Adherent Cells
Applications
Multicentre evaluation of adherent cells frozen on SemaCytes for rapid assays
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SemaCyte® Microcarriers Material Properties
Platform
An overview of the unique material properties achieved via semiconductor fabrication.
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SemaCyte® Cell Assaying Microcarriers
Platform
The features and advantages of Semarion's cell assaying platform
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