The SemaCyte® Microcarrier Platform

SemaCyte® cell assaying microcarriers leverage novel materials physics to move and freeze cells while retaining their adherent morphology. This approach introduces flexibility, speed, and miniaturisation into existing drug discovery workflows. We enhance standard cell assays to produce better data, faster.

SemaCytes function as ultra-miniaturised, mobile wells which carry small colonies of adherent cells. These flat, walled cell microcarriers can be moved with liquid handling tools and their orientation can be controlled magnetically. SemaCytes can be used to measure additional experimental endpoints, prepare adherent assay-ready cells, and reduce the number of cells per well.

Enabling More Powerful Workflows with Cell Microcarriers

Move cells
while retaining their
adherent morphology

Increase assay flexibility and enable further workflow automation

e.g. subsample adherent cells to measure additional endpoints

Freeze adherent assay-ready cells in cryovials for on-demand use

Reduce assay preparation time to increase throughput by 2- to 20-fold

e.g. adherent assay-ready cells for rapid design-make-test-analyse cycles

 

Place less cells per well
while still retaining
high local confluency

Reduce the amount of adherent
cells per assay by 5- to 50-fold

e.g. ultra-miniaturise assays with primary cell materials in 96- or 384-well plates
Our SemaCyte Starter Kit is available through our Early Adopter Programme. For use cases and examples, have a look at the product page or our brochure.

Seamless Integration with Workflows

Clieck here to watch our SemaCyte Microcarrier webinar to learn more.

SemaCytes are created with microfabrication technologies, combining nanomagnetism, smart materials, and surface engineering.

Cell seeding can be done as usual by simply pipetting cells on arrays of immobilised SemaCytes.

Once the correct confluency and morphology is achieved, the SemaCytes are released into suspension for direct use or cryopreservation.

Cell-containing SemaCytes are dispensed into a well plate for screening assays involving plate readers or microscopes.

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SemaCyte® cell microcarriers are magnetically controlled, but do not interact with each other.

SemaCyte® Microcarriers Platform – Brochure

Platform
The SemaCyte® Microcarrier Platform leverages novel materials physics to move and freeze adherent cells. Our approach introduces flexibility, speed, and into existing drug discovery workflows.
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Protocol for the Preparation and Use of SemaCytes

Platform
Overview of how to generate and use SemaCytes for standard cell assays
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