The SemaCyte® Platform
Adherent cells are the cornerstone of drug discovery research. These cell types need to be attached to a surface or substrate which drastically reduces workflow flexibility, requires high numbers of cells-per-assay, and leads to batch variability.
Our solution is simple. Keep colonies of cells attached to a flat surface, but bring this surface into suspension. This is possible with our SemaCytes. These mobile islands carry adherent cells and function as ultra-miniaturized, steerable wells to produce better data, faster.
Enabling More Powerful Workflows
Move and freeze cells
while retaining their
adherent morphology
Increase assay flexibility,
throughput, and reliability
e.g. adherent assay-ready cells for rapid design-make-test-analyse cycles
Multiplex multiple cell
types in a single well
with optical barcodes
Reduce the time andcost for
screening large cell panels
e.g. multiplexing cell models for rapid drug positioning and profiling
Place less cells per well
while still retaining
high local confluency
Reduce the amount of adherent
cells per assay by 5- to 50-fold
e.g. ultra-miniaturize assays with primary cell materials in 96- or 384-well plates
Seamless Integration with Workflows
SemaCytes are created with microfabrication technologies, combining nanomagnetism, smart materials, and surface engineering.
Cell seeding can be done as usual by simply pipetting cells on arrays of immobilised SemaCytes.
Once the correct confluency and morphology is achieved, the SemaCytes are released into suspension for direct use or cryopreservation.
Cell-containing SemaCytes are dispensed into a well plate for screening assays involving plate readers or microscopes.